Our Research

2025

Leite-Gomes, E. , Silva, M. C., Dias, A. M., Fernandes, A., Faria, G., Nogueira, R., Santos-Pereira, B., Fernandes-Mendes, H., Azevedo, C. M., Raposo, J., López Portero, J., de Alda Catalá, T., Taxonera, C., Lago, P., Fernandez-Aceñero, M. J., Rosa, I., Marcos-Pinto, R., Pinho, S.S.. (2025). T-cell branched glycosylation as a mediator of colitis-associated colorectal cancer progression: a potential new risk biomarker in inflammatory bowel disease. Journal of Crohn’s and Colitis, 19(4), jjaf043


Charneca, S., Hernando, A., Almada-Correia, I., Polido-Pereira, J., Vieira, A., Sousa, J., Santos Almeida, A., Motta, C., Barreto, G., Eklund, K. K., Alonso-Pérez, A., Gómez, R., Cicci, F., Mauro, D., Pinho, S. S., Fonseca, J. E., Costa-Reis, P., & Sousa Guerreiro, C. (2025). TASTY trial: Protocol for a study on the triad of nutrition, intestinal microbiota and rheumatoid arthritis. Nutrition Journal, 24:52.


Rodrigues, C. S., Gaifem, J., Pereira, M. S., Alves, M. F., Silva, M., Padrão, N., … Pinho, S. S. (2025). Alterations in mucosa branched N-glycans lead to dysbiosis and downregulation of ILC3: a key driver of intestinal inflammation. Gut Microbes, 17(1).

 

2024

Gaifem J, Rodrigues CS, Petralia F, Alves I, Leite-Gomes E, Cavadas B, Dias AM, Moreira-Barbosa C, Revés J, Laird RM, Novokmet M, Štambuk J, Habazin S, Turhan B, Gümüş ZH, Ungaro R, Torres J, Lauc G, Colombel JF, Porter CK, Pinho SS. (2024) A unique serum IgG glycosylation signature predicts development of Crohn’s disease and is associated with pathogenic antibodies to mannose glycan. Nature Immunology, 25(9):1692-1703.


Almeida P, Fernandes Â, Alves I, Pinho SS. (2024) Glycans in Trained Immunity: Educators of innate immune memory in homeostasis and disease. Carbohydrate Research, 544:109245.


Crouch LI, Rodrigues CS, Bakshani CR, Tavares-Gomes L, Gaifem J, Pinho SS. (2024) The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system. Seminars in Immunology, 9(73):101891.

 

2023

Bondareva, M., Budzinski, L., Durek, P., Witkowski, M., Angermair, S., Ninnemann, J., Kreye, J., Letz, P., Ferreira-Gomes, M., Semin, I., Guerra, G. M., Momsen Reincke, S., Sánchez-Sendin, E., Yilmaz, S., Sempert, T., Heinz, G. A., Tizian, C,, Raftery, M., Schönrich, G., Matyushkina, D., Smirnov, I. V., Govorun, V.M., Schrezenmeier, E., Stefanski, A. L., Dörner, T., Zocche, S., Viviano, E., Klement, N., Sehmsdorf. K. J., Lunin, A., Chang, H. D., Drutskaya, M., Kozlovskaya, L., Treskatsch, S., Radbruch, A., Diefenbach, A., Prüss, H., Enghard, P., Mashreghi, M. F., Kruglov, A. A.. (2023) Cross-regulation of antibody responses against the SARS-CoV-2 Spike protein and commensal microbiota via molecular mimicry. Cell Host Microbe, 31(11):1866-1881.e10.


Clerc, F., Reiding, K. R., de Haan, N., Koeleman, C. A. M., Hipgrave Ederveen, A. L. , Manetti, N.; IBD-BIOM Consortium; Dotz, V., Annese, V., Wuhrer, M.. (2023) Immunoglobulin A glycosylation differs between Crohn’s disease and ulcerative colitis. Journal of Proteome Research, 22(10):3213-3224.


Vicente, M. M., Alves, I., Fernandes, Â., Dias, A. M., Santos-Pereira, B., Pérez-Anton, E., … & Pinho, S. S. (2023). Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity. Cellular & Molecular Immunology, 20(8), 955-968.


Vicente, M. M., Leite-Gomes, E., & Pinho, S. S. (2023). Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications. Trends in Immunology, 40 (8), 585-597.


Pinho, S. S., Alves, I., Gaifem, J., & Rabinovich, G. A. (2023). Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection. Cellular & Molecular Immunology20(10), 1101-1113.