Our Research

2025

Charneca, S., Hernando, A., Almada-Correia, I., Polido-Pereira, J., Vieira, A., Sousa, J., Santos Almeida, A., Motta, C., Barreto, G., Eklund, K. K., Alonso-Pérez, A., Gómez, R., Cicci, F., Mauro, D., Pinho, S. S., Fonseca, J. E., Costa-Reis, P., & Sousa Guerreiro, C. (2025). TASTY trial: Protocol for a study on the triad of nutrition, intestinal microbiota and rheumatoid arthritis. Nutrition Journal, 24:52.

Rodrigues, C. S., Gaifem, J., Pereira, M. S., Alves, M. F., Silva, M., Padrão, N., … Pinho, S. S. (2025). Alterations in mucosa branched N-glycans lead to dysbiosis and downregulation of ILC3: a key driver of intestinal inflammation. Gut Microbes, 17(1).

2024

Gaifem J, Rodrigues CS, Petralia F, Alves I, Leite-Gomes E, Cavadas B, Dias AM, Moreira-Barbosa C, Revés J, Laird RM, Novokmet M, Štambuk J, Habazin S, Turhan B, Gümüş ZH, Ungaro R, Torres J, Lauc G, Colombel JF, Porter CK, Pinho SS. (2024) A unique serum IgG glycosylation signature predicts development of Crohn’s disease and is associated with pathogenic antibodies to mannose glycan. Nature Immunology, 25(9):1692-1703.


Almeida P, Fernandes Â, Alves I, Pinho SS. (2024) Glycans in Trained Immunity: Educators of innate immune memory in homeostasis and disease. Carbohydrate Research, 544:109245.


Crouch LI, Rodrigues CS, Bakshani CR, Tavares-Gomes L, Gaifem J, Pinho SS. (2024) The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system. Seminars in Immunology, 9(73):101891.

2023

Vicente, M. M., Alves, I., Fernandes, Â., Dias, A. M., Santos-Pereira, B., Pérez-Anton, E., … & Pinho, S. S. (2023). Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity. Cellular & Molecular Immunology, 20(8), 955-968.


Vicente, M. M., Leite-Gomes, E., & Pinho, S. S. (2023). Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications. Trends in Immunology, 40 (8), 585-597.


Pinho, S. S., Alves, I., Gaifem, J., & Rabinovich, G. A. (2023). Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection. Cellular & Molecular Immunology20(10), 1101-1113.